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#sars

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##Brain scans of people who’ve had #SARS-CoV-2 show a pattern of brain shrinkage that is distinct from normal aging. The orbitofrontal cortex and parahippocampal gyrus are the regions most likely to be affected post-#infection.

The ORBITAL FRONTAL CORTEX generates much interest because of some of the roles it is speculated to play in higher-order cognition, such as #DecisionMaking . It connects other regions of the brain to the sensory regions, #memory, and #emotion centers. Notable in #covid infections, this part of the brain processes #taste and #smell perception.

Cognitive functions usually associated with the orbitofrontal cortex include:

- Affective responses (emotional reactions)
- Decision making
- Impulse control

Damage to the orbitofrontal cortex may cause changes in social #behavior (how you interact with others and situations), decision making, and #personality.

People with damage to the orbitofrontal cortex may show -

MORE:
- Aggression
- Childish conduct
- Disinhibition
- Apathy
- Risky behavior

and LESS:
- #Motivation
- #Empathy / concern and for others
- Impulse control

Damage to the orbitalfrontal cortex may alter how the body reacts to emotions, leading to impulsivity and bad judgment. For instance, when making a bold decision, healthy patients exhibit physical symptoms of worry, such as sweaty palms. Patients with injury to the orbitofrontal cortex, however, did not.

Studies show that the orbitalfrontal cortex aids in forecasting decisions based on experience. If this part of the brain is damaged, people may make bad choices even though they are aware of the consequences.

ON THE BRIGHT SIDE, some people find that the changes in their brain make them feel happier, unnhibited, less prone to worry, and more animated.

practicalpie.com/orbitofrontal

Practical Psychology · Orbitofrontal CortexDespite being a poorly understood brain region, the orbitofrontal cortex (OFC) generates much interest because of some of the roles it is speculated to

🇩🇪

CN #SARS #CovidIsNotOver #Corona #LongCovid #MECFS #Covid19

Da die offiziellen Zahlen zum aktuellen Infektionsgeschehen um Größenordnungen zu niedrig kommuniziert werden, habe ich für Deutschland und die einzelnen Bundesländer ein Dashboard mit einer Schätzung der realen Zahlen auf Basis der Hospitalisierungen und kalibriert mit Abwasserdaten entwickelt.

Die Daten werden täglich und automatisch aktualisiert.

Weitere Informationen unter:

covidisnotover.info/aktuelle-c

"A French team has recently teased some brand new findings — as yet unpublished — saying they know where the virus has been hiding. ... have found #SARS-nCov-2 hiding in a special type of immune cell called #megakaryocytes. These cells produce the little clotting factors in blood called platelets and — can seed the virus into the platelets. If that leads to problems with blood flow, it could explain many of the problems in #LongCovid, including fatigue and brain fog."
crikey.com.au/2024/12/02/long-

Crikey · Long COVID is becoming a serious social and economic issue for AustraliaJason Murphy poolt
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@RebelGeek99 @mike_honey_ also the fact that the "P.R." China rather covered it up (as that would shed a light on the whole wet market issue and the lack of basic sanitary standards being enforced at all, cuz other places in Asia have wet markets yet they don't have that issue - I wounder why?) since at least August 2019 (when it was widespread knowledge among doctors in China) debunks any "lab leak" theory as the lack of lethality and other key indices point against it.

  • There are way better, more dangerous and more lethal pathogens than #SARS that are way easier to get into a "weapons-grade" configuration. #COVID19 has orders of magnitude too low #lethality and is way too contagious...

There is strong evidence of brain-related abnormalities in COVID-19.

However, it remains unknown whether the impact of #SARS-#CoV-2 infection can be detected in milder cases,
and whether this can reveal possible mechanisms contributing to brain #pathology.

Here we investigated #brain #changes in 785 participants of UK Biobank (aged 51–81 years) who were imaged twice using magnetic resonance imaging,

including 401 cases who tested positive for infection with SARS-CoV-2 between their two scans
—with 141 days on average separating their diagnosis and the second scan
—as well as 384 controls.

The availability of pre-infection imaging data reduces the likelihood of pre-existing risk factors being misinterpreted as disease effects.

We identified significant longitudinal effects when comparing the two groups, including

(1) a greater reduction in grey matter thickness and tissue contrast in the orbitofrontal cortex and parahippocampal gyrus;

(2) greater changes in markers of tissue damage in regions that are functionally connected to the primary olfactory cortex; and

(3) a greater reduction in global brain size in the SARS-CoV-2 cases.

The participants who were infected with SARS-CoV-2 also showed on average a greater cognitive decline between the two time points.

Importantly, these imaging and cognitive longitudinal effects were still observed after excluding the 15 patients who had been hospitalised.

These mainly limbic brain imaging results may be the in vivo hallmarks of a degenerative spread of the disease through olfactory pathways,
of neuroinflammatory events,
or of the loss of sensory input due to anosmia.

Whether this deleterious effect can be partially reversed, or whether these effects will persist in the long term, remains to be investigated with additional follow-up.

nature.com/articles/s41586-022

NatureSARS-CoV-2 is associated with changes in brain structure in UK Biobank - NatureAfter infection with SARS-CoV-2, individuals show a greater reduction in grey matter thickness and tissue contrast in the orbitofrontal cortex and parahippocampal gyrus; greater changes in markers of tissue damage in regions that are functionally connected to the primary olfactory cortex; and a greater reduction in global brain size.

I wonder if there were parallels to this pattern of wildlife infections by humans during past epidemics. The world is much more toxic, now, everything's immune system is depleted.
"The #covid_19 virus is widespread amongst wildlife in the United States.
The greatest exposure was found in animals near hiking trails and high-traffic public areas, suggesting that the virus passed from humans to wildlife. Genetic testing of wild animals confirmed both the presence of #SARS-CoV-2 and the existence of unique viral mutations with lineages that closely matched variants circulating in humans at the time, further supporting the idea of human-to-animal transmission.
Researchers identified the virus in deer mice, Virginia opossums, raccoons, groundhogs, Eastern cottontail rabbits, & Eastern red bats.
One possible COVID source is contaminated wastewater, but they think it’s more likely that trash bins & food waste are the main sources."
forbes.com/sites/grrlscientist

Forbes · COVID-19 Is Widespread In ‘Common Backyard Wildlife’ In USGrrlScientist poolt
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Dr. Chen Chien-Jen was Taiwan’s Premier until last month. He’s also an epidemiologist. He spoke to Elaine Lin of @timkmak’s Counteroffensive about how, because of China’s opposition, Taiwan has been excluded from almost all international organizations, including the World Health Organization.

Dr. Chen was leading the country’s health department at the time of the SARS outbreak in 2003, and witnessed firsthand the devastating effect of this exclusion.

flip.it/jPE6Cr

The Counteroffensive with Tim Mak · China’s war against Taiwan at the World Health OrganizationElaine Lin poolt