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#LongCovid

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🔗 Wearable heart rate variability monitoring identifies autonomic dysfunction and thresholds for post-exertional malaise in Long COVID (preprint)

Heart rate variability, assessed by wearables, confirms autonomic dysfunction in patients with long COVID. The delayed recovery of the sympathovagal balance after exercise close and above to VT1 suggests that VT1 can be practically interpreted as a PEM threshold.

medRxiv · Wearable heart rate variability monitoring identifies autonomic dysfunction and thresholds for post-exertional malaise in Long COVIDObjectives: Patients with Long COVID experience disabling fatigue, autonomic dysfunction, reduced exercise capacity, and post-exertional malaise (PEM). Heart rate variability (HRV) can evaluate autonomic function and monitor overexertion, potentially helping to mitigate PEM. This study aimed to use continuous multi-day HRV recordings to monitor overexertion and study autonomic function in Long COVID. Method: Heart rate and HRV were continuously measured in 127 patients with long COVID (43+/-11 years, 32% male) and 21 healthy controls (42+/-13 years, 48% male), and daily life activities tracked in a logbook. Participants underwent a (sub)maximal cardiopulmonary exercise test to determine heart rate at the first ventilatory threshold (VT1) to study HRV responses to exercise at different intensities. Results: HRV was lower in patients with long COVID compared to healthy controls during various daily activities and sleep (p<0.027). HRV remained lower for 24 hours after exercise below, at or above VT1 in patients, but not in healthy controls (p=0.010). Nighttime HRV decreased with intense exercise and longer durations in patients with long COVID (p=0.018), indicative of exercise-induced diurnal disturbances of the autonomic nervous system in long COVID. Conclusion: Heart rate variability, assessed by wearables, confirms autonomic dysfunction in patients with long COVID. The delayed recovery of the sympathovagal balance after exercise close and above to VT1 suggests that VT1 can be practically interpreted as a PEM threshold. Application: These results confirm the applicability of wearables to assess autonomic function and manage overexertion in long COVID patients. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This study was funded internally by DeSportarts and Vrije Universiteit Amsterdam with support from the ZonMw Consortia voor biomedisch cohortonderzoek naar ME/CVS 2022 and Biomedische kennishiaten post-COVID 2024. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: The medical ethical committee of the Amsterdam UMC waived ethical oversight according to local legislation. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All data produced in the present study are available upon reasonable request to the authors

wbez.org/books/2025/03/20/gret

But Morgan’s voice — her livelihood — would soon be altered by COVID-19. Five years ago this month, the Oak Brook-raised singer contracted the virus, which she believes happened during an Okeechobee, Florida festival where she performed with Vampire Weekend.

“We saw the news that coronavirus was raging through nursing homes in Italy, and there was just a deep sense of foreboding. But it didn’t feel like we were immediately threatened,” she said. “I trusted that we were in safe hands, choosing to play this festival.”

In her forthcoming memoir The Lost Voice (HarperOne), Morgan chronicles how the disease left her voice impaired. “The top half of my range became inaccessible,” she said, “and I began to feel like a stranger in my own body as well.” Now a participant in the Mayo Clinic’s long COVID treatment program, Morgan says is still navigating all of the ways that COVID has shaped her art and life writ large.

greta morgan lede_Misha Handschumacher.png
WBEZ · Musician Greta Morgan lost her voice to long COVID. In a new book, she finds it.The singer-songwriter, formerly of The Hush Sound and Vampire Weekend, says she’s still navigating the impact of the virus on her musicianship and her health.

If you're in Australia and have long covid the National Centre for Neuroimmunology and Emerging Diseases at Griffith uni are after research participants. I spoke to one of the Drs involved yesterday, i'm volunteering for stuff, and he mentioned that they are struggling to get enough participants

Edit: since someone asked and this has gone outside my usual circles, they're able to handle those of us who are housebound. People involved have experience treating ME/CFS people

griffith.edu.au/research/healt

www.griffith.edu.auParticipate

Fünf Jahre nach Beginn der #Corona-Pandemie sind die gesundheitlichen Folgen weiter präsent. Schwere akute Verläufe sind zwar für die meisten kein Thema mehr. Problematisch sind aber Langzeitschäden, auch nach milden Verläufen und Reinfektionen.

sn.at/panorama/wissen/post-cov

Salzburger Nachrichten · Post Covid ist auch 5 Jahre nach Pandemiestart ein ProblemSalzburger Nachrichten poolt

You know what might actually help some of us work? A council-run trades service.

I need a weekly cleaner who will actually turn up. I need a plasterer without the ringing round trying to get quotes. I need a decorator without the searching and trying to get recommendations. I need someone I can call to change lightbulbs I can't safely reach and hook the curtain back on its rings.

I'd happily pay the going rate for the work if it got rid of the headaches.

"Those of us who want to take any extra steps to protect ourselves have been largely abandoned. Wearing masks in crowded spaces is rare, mocked, and in some cases even banned. Any kinds of commonsense precaution like air filtration have been shoved on the back burner or worse. The vulnerable are on their own—and there’s little reason to believe that our ranks won’t grow."

archive.md/MDXGt#selection-111

Still mourning what could have been, while everyone mocks me for my caution.

Labour are brutally gutting diability benefits while allowing many more to become disabled.

Research shows that roughly 1 in 10 people in UK have Long Covid, with many more to follow.

Each infection carries risk, not only for LC but many other sequelae.

Covid is an *ongoing* mass disabling event.

theguardian.com/commentisfree/

The Guardian · Long Covid is the pandemic’s dark shadow. Why does no one in power in Britain want to talk about it?Frances Ryan poolt

#Covid19 hospital acquired infections still a major problem, yet precautions are not protecting vulnerable patients.

"We seem to ignore the people at the centre of this. We're dealing with people losing their lives. [The proposal] might benefit the system, but what harm are we causing to patients?"

rnz.co.nz/news/what-you-need-t

#Covid19NZ #CovidIsNotOver #MaskUp #LongCovid #ChronicIllness
@auscovid19

RNZ · Too many catching Covid-19 in hospital, experts say - but precautions being rolled backKatie Kenny poolt